The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
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چکیده
منابع مشابه
The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
Danshensu (3-(3, 4-dihydroxyphenyl) lactic acid), a water-soluble active component isolated from the root of Salvia miltiorrhiza Bunge, is widely used for the treatment of cerebrovascular diseases. The present study aims to investigate the role of P-glycoprotein in transport of Danshensu across the blood-brain barrier. Sprague-Dawley rats were pretreated with verapamil at a dose of 20 mg kg(-1)...
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15 صفحه اولP-glycoprotein restricted transport of nimodipine across blood-brain barrier.
AIM To examine whether the transport of nimodipine (NMD) from the circulating blood into the brain is restricted by P-glycoprotein (P-gp) in rat brain capillary endothelial cells (BCEC). METHODS When cells reached confluence, a time course of NMD uptake was recorded by incubation with a medium containing NMD 10 mg/L at 37 degrees C. Effects of various agents in the steady-state uptake of NMD ...
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The blood-brain barrier is composed of specialized endothelial cells that prevent various substances from entering the brain. P-glycoprotein is an important component of this barrier and is present in high concentration on the apical surface of these endothelial cells. It is an ATP-dependent transport protein thought to be involved in extruding a variety of structurally unrelated compounds and ...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2011
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2011/713523